# Mechanisms of action and resistance in histone methylation-targeted therapy

*PRI Rank #20 · Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026/rank-20*

| Field | Value |
| --- | --- |
| Rank | #20 |
| 18m citations | 68 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07103-x |
| Corresponding authors | Makoto Yamagishi, Yutaka Suzuki, Kaoru Uchimaru |
| Institution | The University of Tokyo, Japan |

**Ranking page:** [Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026](https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026)

**Paper link:** [10.1038/s41586-024-07103-x](https://doi.org/10.1038/s41586-024-07103-x)

## Topics

H3K27me3 · EZH1-EZH2 dual inhibitor · valemetostat · adult T cell leukaemia/lymphoma · Chromatin condensation · PRC2 · integrative single-cell analyses · resistant clones · PRC2-compound interface mutations · TET2 mutation · DNMT3A expression · de novo DNA methylation · Chromatin condensation · H3K27me3-associated regions · epigenetic resistance mechanisms · tumour suppressor gene reactivation · primary susceptibility subpopulations · chromatin homeostasis · Epigenetic inheritance

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026. https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```