# Histone H3K9 Lactylation Confers Temozolomide Resistance in Glioblastoma via LUC7L2‐Mediated MLH1 Intron Retention

*PRI Rank #18 · Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 74 |
| Journal | Advanced Science |
| Year | 2024 |
| DOI | 10.1002/advs.202309290 |
| Corresponding authors | Boyang Liu, Hongbo Guo |
| Institution | Southern Medical University, China |

**Ranking page:** [Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026](https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026)

**Paper link:** [10.1002/advs.202309290](https://doi.org/10.1002/advs.202309290)

## Topics

histone H3K9 lactylation · temozolomide resistance · glioblastoma · LUC7L2 · MLH1 intron retention · mismatch repair · CUT&Tag · SLAM-seq · LDHA/B · stiripentol · recurrent glioblastoma · Post-translational modification · alternative splicing · epigenetic regulation · multi-omics analysis · blood-brain barrier penetration · Histone lactylation inhibition · combination therapy

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026. https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```