# Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications

*PRI Rank #17 · Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026/rank-17*

| Field | Value |
| --- | --- |
| Rank | #17 |
| 18m citations | 74 |
| Journal | Nature Genetics |
| Year | 2024 |
| DOI | 10.1038/s41588-024-01706-w |
| Corresponding authors | Jamie A. Hackett |
| Institution | European Molecular Biology Laboratory (EMBL), Italy |

**Ranking page:** [Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026](https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026)

**Paper link:** [10.1038/s41588-024-01706-w](https://doi.org/10.1038/s41588-024-01706-w)

## Topics

epigenome editing · Chromatin modification · H3K4me3 · H3K27me3 · H2AK119ub · single-cell transcriptional readouts · promoter targeting · Chromatin remodeling · DNA sequence motifs · cis-regulatory context · combinatorial modifications · silencing penetrance · modular platform · transcriptional instruction · context-dependent effects · switch-like regulation · attenuative regulation · Histone modification · causal perturbation · transcriptional heterogeneity

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026. https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```