# Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy

*PRI Rank #16 · Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026/rank-16*

| Field | Value |
| --- | --- |
| Rank | #16 |
| 18m citations | 75 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adl4492 |
| Corresponding authors | Ben Youngblood, Caitlin C. Zebley |
| Institution | St. Jude Children's Research Hospital, United States |

**Ranking page:** [Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026](https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026)

**Paper link:** [10.1126/science.adl4492](https://doi.org/10.1126/science.adl4492)

## Topics

Clonal hematopoiesis · T cell stemness · T cell exhaustion · progenitor-exhausted T cells (Tpex) · Dnmt3a · Tet2 · Asxl1 · Immune checkpoint blockade · anti-PD-L1 · chronic antigen exposure · H2AK119ub · polycomb group-repressive deubiquitinase pathway · T cell self-renewal · CD8 T cell differentiation · Epigenetic modification · Anti-tumor immunity · tumor control

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026. https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```