# Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation

*PRI Rank #13 · Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 88 |
| Journal | Journal of Clinical Investigation |
| Year | 2024 |
| DOI | 10.1172/jci176851 |
| Corresponding authors | Dimitris G. Placantonakis, Jeremy N. Rich |
| Institution | University of Pittsburgh Medical Center, United States |

**Ranking page:** [Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026](https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026)

**Paper link:** [10.1172/jci176851](https://doi.org/10.1172/jci176851)

## Topics

glioblastoma · GBM stem cells · histone lactylation · lactate · CBX3 · CD47 · phagocytosis · microglia · macrophages · EP300 · histone acetyltransferase · lactyl-CoA · anti-CD47 therapy · immunosuppressive cytokine profile · Metabolic reprogramming · glycolysis · Immune evasion · epigenetic reprogramming · heterochromatin · tumor-associated macrophages

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026. https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```