# Causality-enriched epigenetic age uncouples damage and adaptation

*PRI Rank #12 · Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 90 |
| Journal | Nature Aging |
| Year | 2024 |
| DOI | 10.1038/s43587-023-00557-0 |
| Corresponding authors | Vadim N. Gladyshev |
| Institution | Brigham and Women's Hospital, United States |

**Ranking page:** [Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026](https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026)

**Paper link:** [10.1038/s43587-023-00557-0](https://doi.org/10.1038/s43587-023-00557-0)

## Topics

Epigenetic age · causality-enriched epigenetic age · DNA methylation · biological aging · damage-adaptation uncoupling · Epigenetic clock · causal inference · aging biomarkers · cellular damage · adaptive responses · DNA methylation patterns · aging mechanisms

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026. https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```