# Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

*PRI Rank #1 · Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 265 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07019-6 |
| Corresponding authors | Konstantinos Hatzikotoulas |
| Institution | University of Manchester, United Kingdom |

**Ranking page:** [Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026](https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026)

**Paper link:** [10.1038/s41586-024-07019-6](https://doi.org/10.1038/s41586-024-07019-6)

## Topics

type 2 diabetes pathophysiology · multi-ancestry genome-wide association study · 1,289 independent association signals · 611 loci · eight non-overlapping clusters · cardiometabolic trait associations · cell-type-specific open chromatin · pancreatic islets · adipocytes · endothelial cells · enteroendocrine cells · cluster-specific partitioned polygenic scores · coronary artery disease · peripheral artery disease · end-stage diabetic nephropathy · obesity-related processes · single-cell epigenomics · aetiological heterogeneity · genetically informed diabetes care

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026. https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```