# Global marine microbial diversity and its potential in bioprospecting

*PRI Rank #1 · Topics and Trends in Most Cited Enzyme Production and Characterization Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/enzyme-production-and-characterization/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 128 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07891-2 |
| Corresponding authors | Ying Sun, Thomas Möck, Shengying Li, Wenwei Zhang, Guangyi Fan |
| Institution | BGI Research, China |

**Ranking page:** [Topics and Trends in Most Cited Enzyme Production and Characterization Papers, Class of 2026](https://pri.pepkio.com/top-papers/enzyme-production-and-characterization/2026)

**Paper link:** [10.1038/s41586-024-07891-2](https://doi.org/10.1038/s41586-024-07891-2)

## Topics

marine metagenomes · bacterial and archaeal genomes · CRISPR–Cas systems · antibiotic resistance genes · CRISPR–Cas9 system · antimicrobial peptides · PET-degrading enzymes · in silico bioprospecting · genome size evolution · microbial diversity · Biotechnological applications · biomedical applications · global-scale sequencing · bacterial phyla · archaeal phyla · trade-offs between defense and resistance · marine bacterial evolution · metagenome-assembled genomes · enzyme discovery · marine genomic diversity

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Enzyme Production and Characterization Papers, Class of 2026. https://pri.pepkio.com/top-papers/enzyme-production-and-characterization/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```