# The PARP1 selective inhibitor saruparib (AZD5305) elicits potent and durable antitumor activity in patient-derived BRCA1/2-associated cancer models

*PRI Rank #9 · Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 48 |
| Journal | Genome Medicine |
| Year | 2024 |
| DOI | 10.1186/s13073-024-01370-z |
| Corresponding authors | Alba Llop‐Guevara, Judith Balmaña, Violeta Serra |
| Institution | Vall d'Hebron Institute of Oncology (VHIO), Spain |

**Ranking page:** [Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026)

**Paper link:** [10.1186/s13073-024-01370-z](https://doi.org/10.1186/s13073-024-01370-z)

## Topics

saruparib (AZD5305) · PARP inhibitor · olaparib · BRCA1/BRCA2 pathogenic alterations · PALB2 · Homologous recombination deficiency · Patient-derived xenograft models · reversion mutations · hypomorphic BRCA1 · RAD51 foci formation · Replication stress · Genomic instability · ceralasertib · ATR inhibitor · carboplatin combination · PARP inhibitor resistance · preclinical complete response rate · synthetic lethality

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```