# Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase

*PRI Rank #8 · Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 65 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07318-y |
| Corresponding authors | Matthew P. Patricelli, Todd M. Kinsella |
| Institution | Vividion Therapeutics, United States |

**Ranking page:** [Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026)

**Paper link:** [10.1038/s41586-024-07318-y](https://doi.org/10.1038/s41586-024-07318-y)

## Topics

WRN helicase · covalent allosteric inhibitor · Chemoproteomics · allosteric inhibition · covalent inhibitors · helicase inhibition · target discovery · Chemoproteomics · allosteric site · covalent drug discovery

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```