# Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers

*PRI Rank #7 · Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 69 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07350-y |
| Corresponding authors | Henrik Möbitz, Marta Cortés-Cros |
| Institution | Novartis BioMedical Research, Switzerland |

**Ranking page:** [Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026)

**Paper link:** [10.1038/s41586-024-07350-y](https://doi.org/10.1038/s41586-024-07350-y)

## Topics

WRN inhibitor · HRO761 · synthetic lethality · Microsatellite instability · Microsatellite instability · WRN helicase · allosteric inhibition · D1 helicase domain · D2 helicase domain · DNA damage induction · p53-independent mechanism · WRN degradation · microsatellite-stable cells · Patient-derived xenograft models · Microsatellite instability · immune checkpoint inhibitors · genetic screens · pharmacological validation · oral treatment · tumor growth inhibition

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```