# Cell-type-specific CAG repeat expansions and toxicity of mutant Huntingtin in human striatum and cerebellum

*PRI Rank #4 · Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026/rank-4*

| Field | Value |
| --- | --- |
| Rank | #4 |
| 18m citations | 76 |
| Journal | Nature Genetics |
| Year | 2024 |
| DOI | 10.1038/s41588-024-01653-6 |
| Corresponding authors | Nathaniel Heintz |
| Institution | The Rockefeller University, United States |

**Ranking page:** [Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026)

**Paper link:** [10.1038/s41588-024-01653-6](https://doi.org/10.1038/s41588-024-01653-6)

## Topics

CAG repeat expansions · mutant Huntingtin · striatum · cerebellum · medium spiny neurons · cholinergic interneurons · Purkinje neurons · fluorescence-activated nuclear sorting · MSH2 · MSH3 · MutSβ · FAN1 · mutant ATXN3 · SCA3 · somatic instability · cell-type-specific degeneration · nucleolytic excision · CAG slip-outs · striatal toxicity

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```