# PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends

*PRI Rank #3 · Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 76 |
| Journal | Cell |
| Year | 2024 |
| DOI | 10.1016/j.cell.2024.01.015 |
| Corresponding authors | Simon Alberti |
| Institution | Technische Universität Dresden, Germany |

**Ranking page:** [Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026)

**Paper link:** [10.1016/j.cell.2024.01.015](https://doi.org/10.1016/j.cell.2024.01.015)

## Topics

DNA double-strand breaks · DSB sites · PARP1 · PARP1 · PARylation · PARylation · PARP1-DNA co-condensation · DNA end synapsis · bottom-up biochemistry reconstitution · PARP1 multimers · Biomolecular condensates · FUS · FUS · DNA end tethering · mechanical forces on DNA · effector protein recruitment · hierarchical DSB condensate assembly · DNA repair · broken DNA end stabilization · PARP1 release from DNA

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```