# Transcription–replication conflicts underlie sensitivity to PARP inhibitors

*PRI Rank #2 · Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026/rank-2*

| Field | Value |
| --- | --- |
| Rank | #2 |
| 18m citations | 112 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07217-2 |
| Corresponding authors | Thanos D. Halazonetis |
| Institution | University of Geneva, Switzerland |

**Ranking page:** [Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026)

**Paper link:** [10.1038/s41586-024-07217-2](https://doi.org/10.1038/s41586-024-07217-2)

## Topics

PARP inhibitor · PARP1 · Homologous recombination deficiency · Transcription-replication conflicts · PARP1 · TIMELESS · TIPIN · Replication fork protection · early S phase · synthetic lethality · DNA double-strand breaks · trapped PARPs · transcription elongation inhibition · PARP1 enzymatic activity · HR-deficient cancers · replisome progression

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```