# A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements

*PRI Rank #18 · Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 38 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adj7446 |
| Corresponding authors | Stefano Santaguida |
| Institution | European Institute of Oncology IRCCS, Italy |

**Ranking page:** [Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026)

**Paper link:** [10.1126/science.adj7446](https://doi.org/10.1126/science.adj7446)

## Topics

p62/SQSTM1 · micronuclei · chromosomal instability · Chromosomal rearrangements · chromothripsis · Micronucleus rupture · ESCRT-dependent repair · autophagic degradation · mitochondrial proximity · oxidation-driven homo-oligomerization · micronuclear envelope repair · Autophagy receptor · endosomal sorting complex required for transport · Colorectal cancer · prognostic marker

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```