# Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair

*PRI Rank #14 · Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 41 |
| Journal | Nature Cell Biology |
| Year | 2024 |
| DOI | 10.1038/s41556-024-01401-2 |
| Corresponding authors | Tomoo Ogi |
| Institution | Nagoya University, Japan |

**Ranking page:** [Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026)

**Paper link:** [10.1038/s41556-024-01401-2](https://doi.org/10.1038/s41556-024-01401-2)

## Topics

DNA-protein crosslinks (DPCs) · DPCs · aldehyde-induced DNA damage · Transcription-coupled repair · TCR · Ruijs-Aalfs syndrome · Ruijs-Aalfs syndrome · AMeD syndrome · AMeD syndrome · DPC sequencing · formaldehyde-induced DPCs · p97/VCP · proteasome · TFIIS · RNAPII transcript cleavage · Transcription-coupled DPC repair · Transcription-coupled DPC repair · aldehyde clearance · Cockayne syndrome · metabolic genotoxin

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```