# The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance

*PRI Rank #10 · Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026/rank-10*

| Field | Value |
| --- | --- |
| Rank | #10 |
| 18m citations | 48 |
| Journal | Cell |
| Year | 2024 |
| DOI | 10.1016/j.cell.2024.08.001 |
| Corresponding authors | Peter Ly |
| Institution | University of Texas Southwestern Medical Center, United States |

**Ranking page:** [Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026)

**Paper link:** [10.1016/j.cell.2024.08.001](https://doi.org/10.1016/j.cell.2024.08.001)

## Topics

Fanconi anemia pathway · chromothripsis · Extrachromosomal DNA · Chemoresistance · DNA repair · chromosomal instability · Oncogene amplification · Replication stress · genome fragmentation · Resistance mechanisms

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```