# NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance

*PRI Rank #1 · Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 343 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07620-9 |
| Corresponding authors | Yulong He, Axel Behrens, Dong Yin, Changhua Zhang |
| Institution | Sun Yat-sen University, China |

**Ranking page:** [Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026](https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026)

**Paper link:** [10.1038/s41586-024-07620-9](https://doi.org/10.1038/s41586-024-07620-9)

## Topics

NBS1 lactylation · lysine 388 (K388) · Warburg effect · lactate accumulation · Homologous recombination · DNA double-strand breaks · MRN complex · TIP60 · lysine lactyltransferase · HDAC3 · de-lactylase · lactate dehydrogenase A (LDHA) · stiripentol · Chemoresistance · neoadjuvant chemotherapy · Genome integrity · anaerobic glycolysis · DNA repair efficacy

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited DNA Repair Mechanisms Papers, Class of 2026. https://pri.pepkio.com/top-papers/dna-repair-mechanisms/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```