# Gut microbiota regulates stress responsivity via the circadian system

*PRI Rank #6 · Topics and Trends in Most Cited Diet and metabolism studies Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/diet-and-metabolism-studies/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 134 |
| Journal | Cell Metabolism |
| Year | 2024 |
| DOI | 10.1016/j.cmet.2024.10.003 |
| Corresponding authors | John F. Cryan |
| Institution | University College Cork, Ireland |

**Ranking page:** [Topics and Trends in Most Cited Diet and metabolism studies Papers, Class of 2026](https://pri.pepkio.com/top-papers/diet-and-metabolism-studies/2026)

**Paper link:** [10.1016/j.cmet.2024.10.003](https://doi.org/10.1016/j.cmet.2024.10.003)

## Topics

Gut microbiota · stress responsivity · circadian system · Hypothalamic-pituitary-adrenal axis · Hypothalamic-pituitary-adrenal axis · microbial depletion · glucocorticoid rhythmicity · corticosterone · hippocampus · amygdala · circadian pacemaker · sleep/wake transition · time-of-day-specific impairments · microbiota transplantation · diurnal oscillations · Lactobacillus reuteri · Lactobacillus reuteri · brain transcriptome · brain metabolome · stress-sensitive behaviors

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Diet and metabolism studies Papers, Class of 2026. https://pri.pepkio.com/top-papers/diet-and-metabolism-studies/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```