# 5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study

*PRI Rank #19 · Topics and Trends in Most Cited Diet and metabolism studies Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/diet-and-metabolism-studies/2026/rank-19*

| Field | Value |
| --- | --- |
| Rank | #19 |
| 18m citations | 80 |
| Journal | The Lancet Diabetes & Endocrinology |
| Year | 2024 |
| DOI | 10.1016/s2213-8587(23)00385-6 |
| Corresponding authors | Michael EJ Lean |
| Institution | University of Glasgow, United Kingdom |

**Ranking page:** [Topics and Trends in Most Cited Diet and metabolism studies Papers, Class of 2026](https://pri.pepkio.com/top-papers/diet-and-metabolism-studies/2026)

**Paper link:** [10.1016/s2213-8587(23)00385-6](https://doi.org/10.1016/s2213-8587(23)00385-6)

## Topics

DiRECT trial · type 2 diabetes remission · Weight loss maintenance · total diet replacement · formula diet 825-853 kcal/day · antidiabetic drug withdrawal · antihypertensive drug withdrawal · HbA1c · 10 kg weight loss threshold · low-intensity dietary support · stepped food reintroduction · primary care intervention · glucose-lowering medication · BMI greater than 27 kg/m2 · diabetes duration less than 6 years · weight management intervention · 5-year follow-up outcomes · serious adverse events

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Diet and metabolism studies Papers, Class of 2026. https://pri.pepkio.com/top-papers/diet-and-metabolism-studies/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```