# Lithocholic acid phenocopies anti-ageing effects of calorie restriction

*PRI Rank #16 · Topics and Trends in Most Cited Diet and metabolism studies Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/diet-and-metabolism-studies/2026/rank-16*

| Field | Value |
| --- | --- |
| Rank | #16 |
| 18m citations | 84 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-08329-5 |
| Corresponding authors | Cixiong Zhang, Chen-Song Zhang, Sheng‐Cai Lin |
| Institution | Xiamen University, China |

**Ranking page:** [Topics and Trends in Most Cited Diet and metabolism studies Papers, Class of 2026](https://pri.pepkio.com/top-papers/diet-and-metabolism-studies/2026)

**Paper link:** [10.1038/s41586-024-08329-5](https://doi.org/10.1038/s41586-024-08329-5)

## Topics

lithocholic acid · LCA · Caloric restriction · CR · Metabolomics · AMPK · AMPK · muscle regeneration · grip strength · running capacity · Caenorhabditis elegans · Drosophila melanogaster · lifespan extension · healthspan extension · AMPK knockout · bile acid signaling · CR-mediated metabolites · anti-aging intervention

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Diet and metabolism studies Papers, Class of 2026. https://pri.pepkio.com/top-papers/diet-and-metabolism-studies/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```