# The glycolytic enzyme PFKFB3 drives kidney fibrosis through promoting histone lactylation-mediated NF-κB family activation

*PRI Rank #5 · Topics and Trends in Most Cited Dialysis and Renal Disease Management Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/dialysis-and-renal-disease-management/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 91 |
| Journal | Kidney International |
| Year | 2024 |
| DOI | 10.1016/j.kint.2024.04.016 |
| Corresponding authors | Wei Chen, Qinghua Liu, Haiping Mao |
| Institution | Sun Yat-sen University, China |

**Ranking page:** [Topics and Trends in Most Cited Dialysis and Renal Disease Management Papers, Class of 2026](https://pri.pepkio.com/top-papers/dialysis-and-renal-disease-management/2026)

**Paper link:** [10.1016/j.kint.2024.04.016](https://doi.org/10.1016/j.kint.2024.04.016)

## Topics

PFKFB3 · glycolytic reprogramming · histone lactylation · H4K12la · NF-κB signaling activation · Renal fibrosis · Chronic kidney disease · ischemia-reperfusion injury · Proximal tubular epithelial cells · PTC-specific PFKFB3 deletion · PFKFB3 inhibitor · lactate metabolism · IKKβ activation · IκBα · p65 · Ikbkb · Rela · Relb · urinary lactate/creatine ratio · kidney inflammation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Dialysis and Renal Disease Management Papers, Class of 2026. https://pri.pepkio.com/top-papers/dialysis-and-renal-disease-management/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```