# CRISPR-Cas9 Gene Editing with Nexiguran Ziclumeran for ATTR Cardiomyopathy

*PRI Rank #8 · Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 107 |
| Journal | New England Journal of Medicine |
| Year | 2024 |
| DOI | 10.1056/nejmoa2412309 |
| Corresponding authors | Marianna Fontana |
| Institution | University College London, United Kingdom |

**Ranking page:** [Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026](https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026)

**Paper link:** [10.1056/nejmoa2412309](https://doi.org/10.1056/nejmoa2412309)

## Topics

CRISPR-Cas9 gene editing · Nexiguran ziclumeran · ATTR cardiomyopathy · serum TTR level · NT-proBNP · high-sensitivity cardiac troponin T · 6-minute walk distance · NYHA class · variant ATTR-CM · infusion-related reactions · transient liver-enzyme elevations · single intravenous infusion · phase 1 open-label trial · TTR reduction · Nexiguran ziclumeran

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026. https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```