# Targeted genome-modification tools and their advanced applications in crop breeding

*PRI Rank #6 · Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 121 |
| Journal | Nature Reviews Genetics |
| Year | 2024 |
| DOI | 10.1038/s41576-024-00720-2 |
| Corresponding authors | Caixia Gao |
| Institution | Chinese Academy of Sciences, China |

**Ranking page:** [Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026](https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026)

**Paper link:** [10.1038/s41576-024-00720-2](https://doi.org/10.1038/s41576-024-00720-2)

## Topics

targeted genome modification · Plant breeding · Genome editing tools · CRISPR-Cas system · TALENs · zinc finger nucleases · base editors · Prime editing · gene knockout · Targeted DNA insertion · trait improvement · agricultural biotechnology · precision breeding · Off-target editing · delivery methods · regulatory frameworks

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026. https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```