# FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy

*PRI Rank #5 · Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 133 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07242-1 |
| Corresponding authors | Junyun Lai, Paul A. Beavis, Phillip K. Darcy |
| Institution | Peter MacCallum Cancer Centre, Australia |

**Ranking page:** [Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026](https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026)

**Paper link:** [10.1038/s41586-024-07242-1](https://doi.org/10.1038/s41586-024-07242-1)

## Topics

FOXO1 · CAR T cells · stemness · metabolic fitness · solid tumours · CAR T cells · stem-like phenotype · mitochondrial mass · mitochondrial fitness · immunosuppressive tumour microenvironment · T cell persistence · Transcription factors · acute lymphoblastic leukaemia · B cell lymphoma · multiple myeloma · genetic engineering · metabolic dysfunction · therapeutic efficacy

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026. https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```