# Improving prime editing with an endogenous small RNA-binding protein

*PRI Rank #3 · Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 135 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07259-6 |
| Corresponding authors | Britt Adamson |
| Institution | Princeton University, United States |

**Ranking page:** [Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026](https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026)

**Paper link:** [10.1038/s41586-024-07259-6](https://doi.org/10.1038/s41586-024-07259-6)

## Topics

Prime editing · reverse transcription · CRISPR-Cas guide RNAs · prime editing reporters · CRISPR screens · La protein · La protein · PE2 · PE3 · PE4 · PE5 · Prime editing · Prime editing · polyuridine tracts · RNA polymerase III transcripts · PE7 · N-terminal domain of La · Prime editing · Prime editing · Prime editing

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026. https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```