# Structure and repair of replication-coupled DNA breaks

*PRI Rank #18 · Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 73 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.ado3867 |
| Corresponding authors | Raphael Pavani, Veenu Tripathi, André Nussenzweig |
| Institution | National Cancer Institute, United States |

**Ranking page:** [Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026](https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026)

**Paper link:** [10.1126/science.ado3867](https://doi.org/10.1126/science.ado3867)

## Topics

CRISPR-Cas9 nicking enzymes · replication fork collapse · single-strand breaks · leading-strand nicks · lagging-strand nicks · single-ended double-strand breaks · seDSBs · double-ended double-strand breaks · deDSBs · Homology-directed repair · end resection · BRCA1 · 53BP1 · RAD51 filament formation · replication fork stability · HR-deficient cancers · genomic scarring · replication-coupled DNA breaks

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026. https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```