# Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells

*PRI Rank #17 · Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026/rank-17*

| Field | Value |
| --- | --- |
| Rank | #17 |
| 18m citations | 73 |
| Journal | Nature Nanotechnology |
| Year | 2024 |
| DOI | 10.1038/s41565-024-01680-8 |
| Corresponding authors | Daniel J. Siegwart |
| Institution | The University of Texas Southwestern Medical Center, United States |

**Ranking page:** [Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026](https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026)

**Paper link:** [10.1038/s41565-024-01680-8](https://doi.org/10.1038/s41565-024-01680-8)

## Topics

bone-marrow-homing lipid nanoparticles · Genome editing · Hematopoietic stem and progenitor cells · malignant haematopoietic stem cells · diseased haematopoietic stem cells · Lipid nanoparticle · bone marrow targeting · HSC gene therapy · nanoparticle delivery system · Hematological disorders · haematological malignancies

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026. https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```