# In situ targeted base editing of bacteria in the mouse gut

*PRI Rank #16 · Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026/rank-16*

| Field | Value |
| --- | --- |
| Rank | #16 |
| 18m citations | 77 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07681-w |
| Corresponding authors | Jesús Fernández-Rodríguez, Xavier Duportet, David Bikard |
| Institution | Eligo Bioscience, France |

**Ranking page:** [Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026](https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026)

**Paper link:** [10.1038/s41586-024-07681-w](https://doi.org/10.1038/s41586-024-07681-w)

## Topics

Base editing · gut microbiome · phage-derived particle · base editor delivery · Escherichia coli · β-lactamase gene · non-replicative DNA vector · Klebsiella pneumoniae · curli production · pathogenic E. coli · colonizing bacteria · editing efficiency · stable bacterial maintenance · microbiome-targeted therapies · Genome editing tools

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026. https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```