# CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma

*PRI Rank #15 · Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 95 |
| Journal | Cancer Discovery |
| Year | 2024 |
| DOI | 10.1158/2159-8290.cd-24-0102 |
| Corresponding authors | Sumanta K. Pal |
| Institution | City of Hope Comprehensive Cancer Center, United States |

**Ranking page:** [Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026](https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026)

**Paper link:** [10.1158/2159-8290.cd-24-0102](https://doi.org/10.1158/2159-8290.cd-24-0102)

## Topics

CD70-targeted CAR T-cell therapy · CTX130 · CAR T cells · clear cell renal cell carcinoma · clear cell renal cell carcinoma · relapsed/refractory ccRCC · RCC xenograft tumors · dose-limiting toxicity · durable complete response · CTX131 · CAR T cells · synergistic potency edits · CD70+ malignancies · phase I first-in-human clinical trial · disease control rate · CAR T cells

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026. https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```