# Bridge RNAs direct programmable recombination of target and donor DNA

*PRI Rank #14 · Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 98 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07552-4 |
| Corresponding authors | Patrick D. Hsu |
| Institution | Arc Institute, United States |

**Ranking page:** [Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026](https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026)

**Paper link:** [10.1038/s41586-024-07552-4](https://doi.org/10.1038/s41586-024-07552-4)

## Topics

bridge RNA · Programmable recombination · Programmable recombination · target-binding loop · donor-binding loop · Programmable recombination · Programmable recombination · Targeted DNA insertion · Programmable recombination · Programmable recombination · nucleic-acid-guided systems · structured non-coding RNA · mobile genetic elements · genome design · genomic rearrangements

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026. https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```