# Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR–Cas9 ribonucleoprotein

*PRI Rank #12 · Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 105 |
| Journal | Nature Biotechnology |
| Year | 2024 |
| DOI | 10.1038/s41587-024-02437-3 |
| Corresponding authors | Niren Murthy, Jennifer A. Doudna |
| Institution | University of California Berkeley, United States |

**Ranking page:** [Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026](https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026)

**Paper link:** [10.1038/s41587-024-02437-3](https://doi.org/10.1038/s41587-024-02437-3)

## Topics

Lipid nanoparticle · CRISPR-Cas9 · Ribonucleoprotein · Geobacillus stearothermophilus · GeoCas9 · GeoCas9 · GeoCas9 · RNP-LNP complexes · In vivo genome editing · Homology-directed repair · Single-stranded DNA templates · tissue-selective LNP formulations · liver editing · lung editing · Intravenous administration · SFTPC gene · biodegradable LNPs · nonviral delivery

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026. https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```