# Durable and efficient gene silencing in vivo by hit-and-run epigenome editing

*PRI Rank #11 · Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026/rank-11*

| Field | Value |
| --- | --- |
| Rank | #11 |
| 18m citations | 105 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07087-8 |
| Corresponding authors | Angelo Lombardo |
| Institution | IRCCS San Raffaele Scientific Institute, Italy |

**Ranking page:** [Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026](https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026)

**Paper link:** [10.1038/s41586-024-07087-8](https://doi.org/10.1038/s41586-024-07087-8)

## Topics

hit-and-run epigenome editing · Epigenetic silencing · Pcsk9 · zinc-finger proteins · Lipid nanoparticle · mRNA delivery · epigenetic repressive marks · liver regeneration · heritability of epigenetic state · EvoETR · EvoETR · DNA-binding platform · cholesterol homeostasis · hepatocytes · transient editor delivery · gene silencing without DNA breaks · in vivo epigenetic therapeutics

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited CRISPR and Genetic Engineering Papers, Class of 2026. https://pri.pepkio.com/top-papers/crispr-and-genetic-engineering/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```