# Single‐extracellular vesicle (EV) analyses validate the use of L1 Cell Adhesion Molecule (L1CAM) as a reliable biomarker of neuron‐derived EVs

*PRI Rank #3 · Topics and Trends in Most Cited Cell Adhesion Molecules Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cell-adhesion-molecules-research/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 54 |
| Journal | Journal of Extracellular Vesicles |
| Year | 2024 |
| DOI | 10.1002/jev2.12459 |
| Corresponding authors | Carlos Nogueras‐Ortiz, Dimitrios Kapogiannis |
| Institution | National Institutes of Health, United States |

**Ranking page:** [Topics and Trends in Most Cited Cell Adhesion Molecules Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/cell-adhesion-molecules-research/2026)

**Paper link:** [10.1002/jev2.12459](https://doi.org/10.1002/jev2.12459)

## Topics

neuron-derived extracellular vesicles · L1CAM · L1CAM · single-EV analysis · β-III-tubulin · GAP43 · VAMP2 · L1CAM ectodomain epitopes · L1CAM-positive EVs · plasma NDEVs · CNS disorder biomarkers · fluid-phase L1CAM · EV cargo analysis · neuronal protein co-expression · immunocapture enrichment

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cell Adhesion Molecules Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/cell-adhesion-molecules-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```