# Clinicopathological analysis of claudin 18.2 focusing on intratumoral heterogeneity and survival in patients with metastatic or unresectable gastric cancer

*PRI Rank #15 · Topics and Trends in Most Cited Cell Adhesion Molecules Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cell-adhesion-molecules-research/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 31 |
| Journal | ESMO Open |
| Year | 2024 |
| DOI | 10.1016/j.esmoop.2024.104000 |
| Corresponding authors | Hye Seung Lee |
| Institution | Seoul National University Hospital, South Korea |

**Ranking page:** [Topics and Trends in Most Cited Cell Adhesion Molecules Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/cell-adhesion-molecules-research/2026)

**Paper link:** [10.1016/j.esmoop.2024.104000](https://doi.org/10.1016/j.esmoop.2024.104000)

## Topics

CLDN18.2 · CLDN18.2 · intratumoral heterogeneity · metastatic gastric cancer · unresectable gastric cancer · tissue microarray · HER2 · PD-L1 · FGFR2 · Epstein-Barr virus · EBV-positive gastric cancer · microsatellite instability · CD8+ T-cell density · Immunohistochemistry · overall survival · fluoropyrimidine plus platinum · trastuzumab · ramucirumab · immuno-oncologic agents · CLDN18.2-positive/PD-L1-high

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cell Adhesion Molecules Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/cell-adhesion-molecules-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```