# Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer’s disease

*PRI Rank #13 · Topics and Trends in Most Cited Cell Adhesion Molecules Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cell-adhesion-molecules-research/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 35 |
| Journal | Acta Neuropathologica |
| Year | 2024 |
| DOI | 10.1007/s00401-024-02721-1 |
| Corresponding authors | Çağhan Kızıl, Badri N. Vardarajan |
| Institution | Columbia University, United States |

**Ranking page:** [Topics and Trends in Most Cited Cell Adhesion Molecules Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/cell-adhesion-molecules-research/2026)

**Paper link:** [10.1007/s00401-024-02721-1](https://doi.org/10.1007/s00401-024-02721-1)

## Topics

APOEε4 · Alzheimer's disease · Fibronectin · rs140926439 · collagen type VI alpha 2 chain (COL6A2) · Extracellular matrix · blood-brain barrier (BBB) · whole-genome sequencing (WGS) · rare coding variants · protective genetic variation · FN1 loss-of-function · zebrafish models · gliosis · gliovascular remodeling · microglial response · vascular deposition · age at onset · APOEε4 homozygous carriers · NIA-AD FBS cohort · toxic protein clearance

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cell Adhesion Molecules Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/cell-adhesion-molecules-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```