# Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancers

*PRI Rank #8 · Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 67 |
| Journal | Nature Cancer |
| Year | 2024 |
| DOI | 10.1038/s43018-024-00754-9 |
| Corresponding authors | Emilie A. Chapeau, Tobias Schmelzle |
| Institution | Novartis BioMedical Research, Switzerland |

**Ranking page:** [Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026)

**Paper link:** [10.1038/s43018-024-00754-9](https://doi.org/10.1038/s43018-024-00754-9)

## Topics

YAP-TEAD protein-protein interaction · Hippo pathway · IAG933 · direct interface disruption · TEAD lipid pocket · YAP eviction from chromatin · TEAD paralogs · mesothelioma · RAS-MAPK pathway · KRAS mutation · RTK inhibitors · MAPK inhibitors · combination therapy · lung cancer · pancreatic cancer · colorectal cancer · Hippo-mediated transcription · Tumor regression · YAP oncogenic functions

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```