# Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers

*PRI Rank #7 · Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 69 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07350-y |
| Corresponding authors | Henrik Möbitz, Marta Cortés-Cros |
| Institution | Novartis BioMedical Research, Switzerland |

**Ranking page:** [Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026)

**Paper link:** [10.1038/s41586-024-07350-y](https://doi.org/10.1038/s41586-024-07350-y)

## Topics

WRN helicase · HRO761 · microsatellite instability · microsatellite instability · synthetic lethality · Allosteric inhibition · D1 and D2 helicase domains · DNA damage · p53-independent mechanism · WRN degradation · microsatellite-stable cells · patient-derived xenograft · colorectal cancer · immune checkpoint inhibitors · RecQ helicase · pharmacological WRN inhibition · genetic screens · microsatellite instability

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```