# Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway

*PRI Rank #5 · Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 85 |
| Journal | Science China Life Sciences |
| Year | 2024 |
| DOI | 10.1007/s11427-023-2499-2 |
| Corresponding authors | Hailin Tang, Jianping Chen |
| Institution | The University of Hong Kong, China |

**Ranking page:** [Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026)

**Paper link:** [10.1007/s11427-023-2499-2](https://doi.org/10.1007/s11427-023-2499-2)

## Topics

Ononin · Triple-negative breast cancer · lung metastasis · EGFR · PI3K/Akt/mTOR pathway · metastasis inhibition · EGFR-mediated signaling · natural compound · Targeted therapy · breast cancer metastasis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```