# Lactate enhances NMNAT1 lactylation to sustain nuclear NAD+ salvage pathway and promote survival of pancreatic adenocarcinoma cells under glucose-deprived conditions

*PRI Rank #18 · Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 40 |
| Journal | Cancer Letters |
| Year | 2024 |
| DOI | 10.1016/j.canlet.2024.216806 |
| Corresponding authors | Huimin Huang, Huajun Yu, Xiaoqun Zheng, Haishan Huang, Linhua Lan |
| Institution | Wenzhou Medical University, China |

**Ranking page:** [Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026)

**Paper link:** [10.1016/j.canlet.2024.216806](https://doi.org/10.1016/j.canlet.2024.216806)

## Topics

lactate · NMNAT1 · Lactylation · nuclear NAD+ salvage pathway · pancreatic adenocarcinoma cells · glucose deprivation · NAD+ metabolism · post-translational modification · metabolic adaptation · cancer cell survival · nutrient stress

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```