# Mechanisms of Response and Tolerance to Active RAS Inhibition in <i>KRAS</i> -Mutant Non–Small Cell Lung Cancer

*PRI Rank #16 · Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026/rank-16*

| Field | Value |
| --- | --- |
| Rank | #16 |
| 18m citations | 45 |
| Journal | Cancer Discovery |
| Year | 2024 |
| DOI | 10.1158/2159-8290.cd-24-0421 |
| Corresponding authors | Ferdinandos Skoulidis |
| Institution | The University of Texas MD Anderson Cancer Center, United States |

**Ranking page:** [Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026)

**Paper link:** [10.1158/2159-8290.cd-24-0421](https://doi.org/10.1158/2159-8290.cd-24-0421)

## Topics

RMC-7977 · RMC-7977 · KRASG12C-mutant NSCLC · inactive state-selective RASG12C inhibitors · RASGTP accumulation · active RAS inhibition · RASG12C(ON) inhibitor resistance · RASG12C(OFF) inhibitor resistance · single-cell transcriptional responses · mucinous transcriptional program · tumor cell persistence · sotorasib · adagrasib · mucinous histologic features · RAS pathway inhibition · covalent targeting of active RASG12C · reversible RASGTP inhibition · comutational models

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```