# TSPAN8 <sup>+</sup> myofibroblastic cancer–associated fibroblasts promote chemoresistance in patients with breast cancer

*PRI Rank #13 · Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 52 |
| Journal | Science Translational Medicine |
| Year | 2024 |
| DOI | 10.1126/scitranslmed.adj5705 |
| Corresponding authors | Guangjian Fan, Bo Yu, Lei Tang, Rongxuan Zhu, Hongxia Wang |
| Institution | Shanghai General Hospital, China |

**Ranking page:** [Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026)

**Paper link:** [10.1126/scitranslmed.adj5705](https://doi.org/10.1126/scitranslmed.adj5705)

## Topics

TSPAN8+ myofibroblastic CAFs · cancer-associated fibroblasts · chemotherapy resistance · breast cancer · single-cell high-dimensional flow cytometry · senescence-associated secretory phenotype · IL-6 · IL-8 · cancer stem cell stemness · SIRT6 · RBBP6 · MAPK11 · RBBP6 Ser772 phosphorylation · GLS1 · PYCR1 · aspartate secretion · proline secretion · metabolic niche · anti-TSPAN8 antibody · MDL-800

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```