# OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response

*PRI Rank #9 · Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 71 |
| Journal | Molecular Cell |
| Year | 2024 |
| DOI | 10.1016/j.molcel.2024.07.020 |
| Corresponding authors | Richard N. Kitsis |
| Institution | Albert Einstein College of Medicine, United States |

**Ranking page:** [Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026)

**Paper link:** [10.1016/j.molcel.2024.07.020](https://doi.org/10.1016/j.molcel.2024.07.020)

## Topics

OPA1 · Ferroptosis · Mitochondrial reactive oxygen species · Integrated stress response · mitochondrial dynamics · Lipid peroxidation · GPX4 · cristae remodeling · iron-dependent cell death · Oxidative stress · Integrated stress response · Mitochondrial function · reactive oxygen species · Cell death

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```