# Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance

*PRI Rank #8 · Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 75 |
| Journal | Cancer Cell |
| Year | 2024 |
| DOI | 10.1016/j.ccell.2024.10.010 |
| Corresponding authors | Heng Lin |
| Institution | University of Michigan, United States |

**Ranking page:** [Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026)

**Paper link:** [10.1016/j.ccell.2024.10.010](https://doi.org/10.1016/j.ccell.2024.10.010)

## Topics

SLC13A3 · SLC1A1 · Ferroptosis · Immune checkpoint blockade · tumor microenvironment · tumor-associated macrophages · Nrf2 · immune-mediated ferroptosis · ACOD1 · SLC13A3 inhibitor · Nrf2 · immunometabolic target · macrophage-derived itaconate · ICB resistance · Tumor immunity · structural modeling · molecular docking

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```