# PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8+ T cell ferroptosis

*PRI Rank #6 · Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 88 |
| Journal | Immunity |
| Year | 2024 |
| DOI | 10.1016/j.immuni.2024.08.003 |
| Corresponding authors | Yi Zhang |
| Institution | Zhengzhou University, China |

**Ranking page:** [Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026)

**Paper link:** [10.1016/j.immuni.2024.08.003](https://doi.org/10.1016/j.immuni.2024.08.003)

## Topics

PD-1 signaling · phospholipid phosphatase 1 · CD8+ T cells · Ferroptosis · T cell exhaustion · Lipid peroxidation · immune checkpoint · tumor microenvironment · Tumor immunity · immunotherapy resistance

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```