# Claudin 18.2 as a novel therapeutic target

*PRI Rank #5 · Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 92 |
| Journal | Nature Reviews Clinical Oncology |
| Year | 2024 |
| DOI | 10.1038/s41571-024-00874-2 |
| Corresponding authors | Lin Shen, Kohei Shitara |
| Institution | National Cancer Center Hospital East, Japan |

**Ranking page:** [Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026)

**Paper link:** [10.1038/s41571-024-00874-2](https://doi.org/10.1038/s41571-024-00874-2)

## Topics

CLDN18.2 · CLDN18.2 · Therapeutic target · gastric cancer · pancreatic cancer · tight junction protein · zolbetuximab · monoclonal antibody therapy · tumor-associated antigen · antibody-drug conjugate · CAR-T cell therapy · Cancer immunotherapy

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```