# Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition

*PRI Rank #3 · Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 108 |
| Journal | Nature Cell Biology |
| Year | 2024 |
| DOI | 10.1038/s41556-024-01464-1 |
| Corresponding authors | Andreas Koeberle, Thomas Brabletz |
| Institution | Friedrich-Alexander University of Erlangen-Nürnberg, Germany |

**Ranking page:** [Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026)

**Paper link:** [10.1038/s41556-024-01464-1](https://doi.org/10.1038/s41556-024-01464-1)

## Topics

ZEB1 · Epithelial-mesenchymal transition (EMT) · Ferroptosis · phospholipid composition · polyunsaturated fatty acids · monounsaturated fatty acids · stearoyl-CoA desaturase 1 · fatty acid synthase · fatty acid desaturase 2 · elongation of very long-chain fatty acid 5 · long-chain acyl-CoA synthetase 4 · TGF-β signaling · therapy resistance · Lipid peroxidation · SCD inhibitors · FADS2 inhibitors · lipogenic enzyme regulation · mesenchymal phenotype · Ferroptosis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```