# Targeted activation of ferroptosis in colorectal cancer via LGR4 targeting overcomes acquired drug resistance

*PRI Rank #19 · Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026/rank-19*

| Field | Value |
| --- | --- |
| Rank | #19 |
| 18m citations | 56 |
| Journal | Nature Cancer |
| Year | 2024 |
| DOI | 10.1038/s43018-023-00715-8 |
| Corresponding authors | Quan Chen |
| Institution | Nankai University, China |

**Ranking page:** [Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026)

**Paper link:** [10.1038/s43018-023-00715-8](https://doi.org/10.1038/s43018-023-00715-8)

## Topics

Ferroptosis · Colorectal cancer · LGR4 · acquired drug resistance · targeted activation · LGR4 targeting

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```