# PTBP1 Lactylation Promotes Glioma Stem Cell Maintenance through PFKFB4-Driven Glycolysis

*PRI Rank #15 · Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 60 |
| Journal | Cancer Research |
| Year | 2024 |
| DOI | 10.1158/0008-5472.can-24-1412 |
| Corresponding authors | Zijian Zhou, Xianyong Yin, Hao Sun |
| Institution | The First Affiliated Hospital of Shandong First Medical University, China |

**Ranking page:** [Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026)

**Paper link:** [10.1158/0008-5472.can-24-1412](https://doi.org/10.1158/0008-5472.can-24-1412)

## Topics

PTBP1 lactylation · Glioma · PFKFB4 · glycolysis · lysine lactylation · SIRT1 · K436 lactylation · TRIM21 · Ubiquitination · RNA-binding capacity · mRNA stabilization · Metabolic reprogramming · epigenetic modifications · polypyrimidine tract-binding protein 1 · lactate accumulation · GSC maintenance · Glioma · RNA processing

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```