# crVDAC3 alleviates ferroptosis by impeding HSPB1 ubiquitination and confers trastuzumab deruxtecan resistance in HER2-low breast cancer

*PRI Rank #12 · Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 66 |
| Journal | Drug Resistance Updates |
| Year | 2024 |
| DOI | 10.1016/j.drup.2024.101126 |
| Corresponding authors | Jindong Xie, Tao Wu, Zhigang Zhou, Xiaoming Xie, Jin Wang |
| Institution | Sun Yat-sen University Cancer Center, China |

**Ranking page:** [Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026](https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026)

**Paper link:** [10.1016/j.drup.2024.101126](https://doi.org/10.1016/j.drup.2024.101126)

## Topics

crVDAC3 · Ferroptosis · HSPB1 · Ubiquitination · trastuzumab deruxtecan · HER2-low breast cancer · drug resistance · VDAC3 · HSPB1 · antibody-drug conjugate resistance

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related molecular mechanisms research Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-mechanisms-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```